FIELD: biotechnology.
SUBSTANCE: method comprises providing a host cell, which is infected with the virus, and the cultivation of the infected host cell at two different temperatures. Then the virus is collected, which is produced by the stages of cultivation. The high titer and increased purity of the virus can be obtained with use of dual temperature cultivation process.
EFFECT: invention can be used in human and veterinary medicine.
25 cl, 31 dwg, 11 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING PREPARATION CONTAINING VIRAL ANTIGENS AND USING PREPARATION | 2008 |
|
RU2496519C2 |
| METHOD OF VIRUS TREATMENT BY ULTRACENTRIFUGATION IN SUGAR CONCENTRATION GRADIENT (VERSIONS) | 2008 |
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| METHOD OF PRODUCING CONTINUOUS CELL LINES AND USE THEREOF | 2009 |
|
RU2509803C2 |
| METHOD FOR LARGE-SCALE PRODUCTION OF VIRAL ANTIGEN | 2002 |
|
RU2314344C2 |
| METHOD OF PROTEIN EXPRESSION | 2007 |
|
RU2486236C2 |
| MEDIUM FOR CELLS CULTIVATION THAT DOES NOT CONTAIN ANIMAL PROTEINS | 2005 |
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| MEDIUM FOR CELL CULTURE THAT DOES NOT CONTAIN OLIGOPEPTIDES | 2017 |
|
RU2758802C2 |
| PERMANENT HUMAN CELL LINES FOR PRODUCING INFLUENZA VIRUSES | 2011 |
|
RU2565546C2 |
| VIRUS VACCINE AND METHODS FOR PRODUCTION THEREOF | 2014 |
|
RU2706693C2 |
| OLIGOPEPTIDE-FREE CELL CULTURE MEDIA | 2013 |
|
RU2642269C9 |
