FIELD: virology.
SUBSTANCE: method involves preparing culture of adhesive cells, their growing, infecting cells with virus and incubation of cells. The density of cells in biomass of cell culture grown before their fusion is increased by at least 1.3-fold as compared with value before and after infecting cell with virus. Method provides enhancing producing virus in small volume of the cellular culture. Invention can be used in medicine and veterinary science.
EFFECT: improved producing method of viral antigen.
13 cl, 4 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTRATE BASED ON CELL CULTURE FOR FLAVIVIRUSES AND ARENOVIRUSES CULTURING AND METHOD OF PREPARING FLAVIVIRUS OR ARENOVIRUS ANTIGEN | 1990 |
|
RU2082757C1 |
| METHOD FOR PREPARATION OF VIRION HERPETIC VACCINE | 1991 |
|
RU2014084C1 |
| METHOD FOR VIRUS REPLICATION IN AVIAN EMBRYO STEM CELLS | 2006 |
|
RU2457253C2 |
| METHOD OF PRODUCTION OF LIVE CULTURE INFLUENZA VIRUS VACCINES | 2003 |
|
RU2330885C2 |
| METHOD OF PHYLOVIRUS SUSPENSION CULTURING IN CELL CULTURE ON MICROCARRIERS | 1993 |
|
RU2076905C1 |
| VIRUS VACCINE AND METHODS FOR PRODUCTION THEREOF | 2014 |
|
RU2706693C2 |
| METHODS FOR CELL CULTURE, VIRUS REPLICATION AND PURIFICATION | 2009 |
|
RU2547587C2 |
| IMPROVED TITRE OF POLYPEPTIDE OF FACTOR VIII IN CELL CULTURES | 2008 |
|
RU2477318C2 |
| PERMANENT HUMAN CELL LINES FOR PRODUCING INFLUENZA VIRUSES | 2011 |
|
RU2565546C2 |
| TWO-STAGE TEMPERATURE PROFILE OF VIRAL CULTIVATION | 2008 |
|
RU2476594C2 |
