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2 477 752

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C1

(51)

IPC

C12N5/789(2010-01-01)

A61K35/407(2006-01-01)

(21) (22)

Application

2012105738/10, 2012-02-17

(24)

Start date

2012-02-17

(22)

Actual filing date

2012-02-17

(45)

Published

2013-03-20

(72)

Inventor

Dygaj Aleksandr MikhajlovichZjuz'Kov Gleb NikolaevichZhdanov Vadim VadimovichUdut Elena VladimirovnaMiroshnichenko Larisa Arkad'EvnaSimanina Elena VladislavnaStavrova Larisa AleksandrovnaGurto Roman VladimirovichChajkovskij Aleksandr Vasil'EvichMarkova Tujana SergeevnaArtamonov Andrej VladimirovichBekarev Andrej AleksandrovichMadonov Pavel Gennad'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Farmakologii" Sibirskogo Otdelenija Rossijskoj Akademii Meditsinskikh Nauk Fgbu Farmakologii" So Ramn

METHOD OF STIMULATING LIVER STEM CELL DIFFERENTIATION IN VITRO IN TISSUE-SPECIFIC DIRECTION Russian patent published in 2013 - IPC C12N5/789 A61K35/407 

Abstract RU 2477752 C1

FIELD: chemistry.

SUBSTANCE: invention relates to biology and cell technologies. Disclosed is a method of stimulating liver stem cell differentiation in a tissue-specific direction, which is achieved due to that liver cells under in vitro conditions are subjected to a culture medium containing 2 U/ml of immobilised hyaluronate-endo-β-N-acetylhexosaminidase for 10 minutes.

EFFECT: method enables, under in vitro conditions, to efficiently stimulate differentiation of liver stem cells in a tissue-specific direction, which can be used in medicine for transplantation purposes.

1 tbl, 1 ex

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RU 2 477 752 C1

Authors

Dygaj Aleksandr Mikhajlovich

Zjuz'Kov Gleb Nikolaevich

Zhdanov Vadim Vadimovich

Udut Elena Vladimirovna

Miroshnichenko Larisa Arkad'Evna

Simanina Elena Vladislavna

Stavrova Larisa Aleksandrovna

Gurto Roman Vladimirovich

Chajkovskij Aleksandr Vasil'Evich

Markova Tujana Sergeevna

Artamonov Andrej Vladimirovich

Bekarev Andrej Aleksandrovich

Madonov Pavel Gennad'Evich

Dates

2013-03-20—Published

2012-02-17—Filed

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