METHOD OF COMBINATION TREATMENT OF LOCALLY ADVANCED GASTRIC CANCER Russian patent published in 2013 - IPC A61N5/10 A61K31/282 A61K31/7068 A61P35/00 A61B17/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly oncology, X-ray therapy, chemotherapy and surgery, and may be used in treating locally advanced gastric cancer. That is ensured by pre-operative radiation therapy covering a primary tumour by deceleration radiation, daily for 24 days with weekend rest by daily dose graduation of three-pole exposure as 1 Gy + 1.5 Gy every 4-5 h between the fractions to SRD 45 Gy. The exposure covers a regional metastasis area with the chemotherapy course comprising the preparations eloxatin and capecitabine. The preparation eloxatin is introduced in a dose of 80 to 85 mg/m² on the 1^st and 21^st days of the chemoradiation therapy. The preparation capecitabine is introduced in a daily dose of 1670 to 2000 mg/m² in 2 stages for the entire course of the radiation therapy including weekends. The first introduction of capecitabine is performed 1 hour before the first session of the exposure. Further, 23-29 days later the chemoradiation therapy is followed by a radical surgical intervention including D2 lymphodissection.

EFFECT: method provides an evident therapeutic effect on the primary tumour and regional metastases with good tolerance and a high degree of anti-cancer effect ensured by reduced micrometastases and tumour complexes circulating in blood and lymph.

4 dwg, 3 ex