FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 1-(2-methyl-4-phenoxyphenyl)-butane-1,3-dione of formula which can be used as a synthon in synthesis of biologically active substances. The method involves reaction of 1-(2-methyl-4-phenoxyphenyl)-ethanone with ethyl acetate in the presence of potassium tert-butoxide in a medium of absolute N,N'-dimethylformamide at temperature of 50-52°C in a nitrogen atmosphere with molar ratio of 1-(2-methyl-4-phenoxyphenyl)-ethanone to ethyl acetate of 1:1.5.
EFFECT: invention enables to obtain the end product using a simple method in a single step.
2 ex
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Authors
Dates
2013-04-10—Published
2012-02-07—Filed