FIELD: chemistry.
SUBSTANCE: method includes reacting a 3-phenoxybenzoic acid derivative with a sodium enolate of acetoacetic ester, wherein the 3-phenoxybenzoic acid derivative used is 3-phenoxybenzoic acid acyl chloride, and the reaction is carried out in molar ratio of reactants of 1:1, in a medium of absolute diethyl ether at room temperature for 3-5 hours, to form ethyl 3-oxo-2-(3-phenoxybenzoyl)butanoate, subsequent hydrolysis thereof in excess water at 100°C for 2 hours.
EFFECT: method reduces the number of synthesis steps, simplifies implementation of the process and enables to obtain an end product with high output.
2 ex
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Authors
Dates
2014-09-27—Published
2013-05-13—Filed