FIELD: chemistry.
SUBSTANCE: invention relates to chemistry of pyrazole derivatives, particularly to a method of producing ethyl 5-methyl-3-(3-phenoxyphenyl)pyrazolyl-4-carboxylate, which is a novel structure 3-phenoxyphenyl-containing compound. Technical result is a wider range of chemical compounds, particularly production of novel ethyl 5-methyl-3-(3-phenoxyphenyl)-1-phenyl-1H-pyrazolyl-4-carboxylate with good output and high degree of purity. Technical result is achieved by a method for producing ethyl 5-methyl-3-(3-phenoxyphenyl)pyrazolyl-4-carboxylate which comprises condensing phenylhydrazine with, obtained by acylating sodium enolate of acetoacetic ester, acyl chloride of 3-phenoxybenzoic acid - ethyl 3-oxo-2-(3-phenoxybenzoyl)butanoate. Condensation is carried out at 80 °C for 2.5 hours, and product is separated by filtration.
EFFECT: obtained novel compound is of interest as an intermediate in synthesis of biologically active compounds.
1 cl, 1 ex
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Authors
Dates
2016-04-20—Published
2015-05-19—Filed