TRICYCLIC SPIRO-DERIVATIVES AS CRTH2 MODULATORS Russian patent published in 2013 - IPC C07D487/10 A61K31/407 A61P29/00 A61P37/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to tricyclic spiro-derivatives of formula (I') wherein: R¹ means H, C₁-C₆-alkyl, C₁-C₆-alkoxy, halogen-C₁-C₆-alkyl, halogen-C₁-C₆-alkoxy, halogen; m is equal to 0-4; R² means A; A means , : n is equal to 1-4; R⁴ means C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₆-C₁₀-aryl, 5, 6-member heteroaryl containing one, two and three heteroatoms independently specified in N, O, S, which may be condensed with a benzene ring; R⁴ may be substituted by one or more groups R⁶; R⁶ means C₁-C₆-alkyl, C₁-C₆-alkoxy, C₆-C₁₀-aryl, C₆-C₁₀-aryl-C₁-C₆-alkyl, C₃-C₈-cycloalkyl, CN, halogen, aminocarbonyl, C₁-C₆-acylamino, C₁-C₆-alkylsulphonyl, trihalogen-C₁-C₆-alkyl, -O-phenyl wherein phenyl may be substituted by one or two substituted specified in halogen, C₁-C₆-alkoxy; R⁷ means H, and C₁-C₆-alkyl; R means B; B means: , n is equal to 1-4; R⁵ means COOH, tetrazole; X means CH₂, NH; Y means C(O); Z means C(O); as well as its geometric isomers, optically active forms, such as enantiomers, diastereomers, its racemate forms, or its pharmaceutically acceptable salts.

EFFECT: compounds are used for treating and/or preventing allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component.

23 cl, 3 tbl, 125 ex