FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention refers to a compound which are auristatin analogues and possess cytotoxic and/or antimitotic activity. Also described are conjugates of such compounds with an antibody or antibody fragment, intended for delivery to a target cancer cell, pharmaceutical compositions containing compounds or their conjugates.
EFFECT: compounds are intended for treating cancer, which is a solid tumor or lymphoma.
34 cl, 7 tbl, 13 ex, 11 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| SULFONAMIDE-CONTAINING BINDING SYSTEMS FOR MEDICINAL CONJUGATES | 2014 |
|
RU2729194C2 |
| TETRAHYDROBENZIMIDAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS | 2014 |
|
RU2684637C1 |
| TREATING CONDITIONS ASSOCIATED WITH HYPERINSULINEMIA | 2015 |
|
RU2722179C2 |
| PURINE DERIVATIVES AS TNF ACTIVITY MODULATORS | 2014 |
|
RU2684644C1 |
| IMIDAZOTRIAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2677699C1 |
| NEW FIVE-MEMBER HETEROCYCLES, THEIR PREPARING, THEIR APPLYING AND PHARMACEUTICAL PREPARATIONS COMPRISING THEREOF | 1998 |
|
RU2240326C2 |
| PYRAZOLOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | 2015 |
|
RU2733400C2 |
| METHOD OF TREATMENT OR PROPHYLAXIS OF MAMMALS AND HUMAN WITH VOMITING USING SOME QUINUCLIDINE, PIPERIDINE, AZANORBORNANE, ETHYLENEDIAMINE DERIVATIVES AND RELATED COMPOUNDS | 1994 |
|
RU2135179C1 |
| COMPOSITION FOR PREPARING METATHESIS POLYMERIZATES | 1995 |
|
RU2171815C2 |
| LOCALLY ADMINISTERED COMPOSITION FOR CONTROL OF ANIMAL PARASITES AND THEIR PREVENTION | 2018 |
|
RU2786638C2 |
