FIELD: chemistry.
SUBSTANCE: invention relates to the chemical and pharmaceutical industry and a method of producing a disodium salt of 3-sulphate betulinic acid - a biologically active substance which is a complement inhibitor and is of great interest in medicine. Betulinic acid is sulphated in N,N-dimethylformamide with a SO3-dimethylformamide complex at temperature of 30-50°C for 3-4 hours, followed by treatment of the reaction mixture with 75% water-ethanol solution and separating the end product.
EFFECT: wider range of sulphating agents, simplification of the process by avoiding use of liquid SO3.
1 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING BETULINIC ACID 3-SULPHATE DISODIUM SALT | 2012 |
|
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|
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|
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|
RU2540085C1 |
