FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry and concerns a method for preparing betulin 3-acetate-28-sulphate sodium salt that is a biologically active substance being of the utmost interest for medicine. Betulin 3-acetate is sulphated in 1,4-dioxane by the SO3-dioxane complex at temperature 20-30°C for 2-3 hours; the reaction mixture is thereafter processed in 75% water-ethanol solution containing 4% sodium hydroxide to pH 7-8 to recover an end product.
EFFECT: synthesis of new water-soluble sulphated betulin derivatives, extended range of the sulphatising agent, simplified process ensured by using liquid SO3.
1 cl, 1 ex
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|
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