HIV-INHIBITING 5-AMIDO-SUBSTITUTED PYRIMIDINES Russian patent published in 2013 - IPC C07D401/12 C07D405/12 C07D409/12 C07D417/12 A61K31/506 A61P31/18 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new pyrimidine derivatives and their pharmaceutically acceptable salts possessing the properties of a HIV replication inhibitor. In formula (I'): , R¹ means a hydrogen atom; R⁷ means a hydrogen atom; C_1-6alkyl; R⁸ means a hydrogen atom; C_1-6alkyl; R⁴ means cyano; R⁹ means -CH=CH-CN; R⁵ means C_3-7cycloalkyl; C_1-6alkyloxy; aryl; Het; C_1-6alkyl substituted by a radical specified in hydroxy, C_1-6alkyloxy, cyano, amino, mono- and di-C_1-6alkylamino, C_1-6alkylcarbonylamino, aryl, Het, dioxoalanine optionally substituted by one or two C_1-6alkyl radicals, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl optionally substituted by C_1-6alkyl or C_1-6alkylcarbonyl, C_1-6alkyloxycarbonyl, aryl C_1-6alkyloxycarbonyl and C_3-7cycloalkyl; or R⁵ means C_1-6alkyl substituted by two C_1-6alkyloxy radicals; R⁶ means a hydrogen atom or C_1-6alkyl; X means -NR¹- or -O; the values of Het are presented in the patent claim. The invention also refers to a pharmaceutical composition containing said compounds.

EFFECT: preparing the pharmaceutically acceptable salts possessing the properties of a HIV replication inhibitor.

9 cl, 2 tbl, 7 ex