FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to isoxazole derivatives of formula
and their pharmaceutically acceptable salts wherein X-Y is N-O or O-N; R1 is independently specified in a group consisting of halogen and C1-4alkyl; or two substitutes R1 together with carbon atoms whereto attached form a 6-member aromatic cycle; R2 represents hydroxy-C1-8alkyl; a is equal to 1, each of m and n is independently equal to 0, 1 or 2. Also, the invention refers to a pharmaceutical composition possessing type 1 11β-hydroxysteroid dehydrogenase inhibitory activity and containing the compounds of formula (I), to the use of the mentioned compounds for producing a drug preparation for treating or preventing glaucoma, as well as to a method of treating glaucoma.
EFFECT: compounds of formula (I) as type 1 11β-hydroxysteroid dehydrogenase inhibitors.
9 cl, 2 dwg, 28 ex
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