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2 564 022

(13)

(51)

IPC

C07D207/16(2006-01-01)

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

A61K31/401(2006-01-01)

A61K31/454(2006-01-01)

A61K31/497(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012138257/04, 2011-02-04

(24)

Start date

2011-02-04

(22)

Actual filing date

2011-02-04

(45)

Published

2015-09-27

(72)

Inventor

Dejvid Dzhozef BartkovitsSin'Tszi ChuTsintszi DinNan' JanTszin'Tszun' LjuTina Morgan RossTszin ChzhanChzhumin Chzhan

(73)

Holder

F.Khoffmann-Lja Rosh Ag

SUBSTITUTED PYRROLIDIN-2-CARBOXAMIDE Russian patent published in 2015 - IPC C07D207/16 C07D401/12 C07D403/12 A61K31/401 A61K31/454 A61K31/497 A61P35/00

Abstract RU 2564022 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to specific derivatives of pyrrolidine-2-carboxamides specified in point 1 of the patent claim, and their pharmaceutically acceptable salts. The invention also refers to a pharmaceutical composition inhibiting the p53 and MDM2 reaction and to using the above compounds for treating cancer.

EFFECT: derivatives of pyrrolidine-2-carboxamide as p53 and MDM2 protein reaction inhibitors applicable for treating cancer.

11 cl, 475 ex

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RU 2 564 022 C2

Authors

Dejvid Dzhozef Bartkovits

Sin'Tszi Chu

Tsintszi Din

Nan' Jan

Tszin'Tszun' Lju

Tina Morgan Ross

Tszin Chzhan

Chzhumin Chzhan

Dates

2015-09-27—Published

2011-02-04—Filed