HETEROCYCLIC COMPOUNDS POSSESSING ELASTASE-INHIBITORY ACTIVITY AND THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION AND AGENT BASED ON THEREOF Russian patent published in 2008 - IPC C07K5/83 A61K38/55 A61P11/00 A61P43/00 

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention describes heterocyclic compounds represented by the general formula (I): and possessing elastase-inhibitory activity, and intermediate compounds for synthesis of such compounds. In the formula (I) R¹ represents heterocyclic group represented by the formula (II): wherein A represents presence or absence of benzene ring; X represents oxygen atom, sulfur atom or -NH; Y represents nitrogen atom or -CH. Indicated heterocyclic group can be substituted with 1-3 substitutes that can be similar or different and they are chosen from group consisting of lower alkyl, lower alkoxy group and phenyl that can be optionally substituted with halogen-containing lower alkyl, lower alkoxy group or halogen atom; each among R² and R³ represents hydrogen atom or hydroxyl, or R² and R³ can be combined to form oxo group under condition that both are not hydrogen atoms.

EFFECT: valuable biochemical property of compounds.

8 cl, 7 tbl