AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVE Russian patent published in 2013 - IPC C07D413/06 C07D413/14 A61K31/5377 A61K31/553 A61P1/00 A61P13/02 A61P13/08 A61P25/18 A61P25/22 A61P25/24 A61P25/28 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (1), in which Ar is a group of formula (Ar-1) or (Ar-2), in which R¹ is a halogen, R² is hydrogen, R³ is hydrogen, R⁴ is hydrogen, alkyl or alkenyl, X is a nitrogen atom or CH, R⁵ and R⁶ are each hydrogen and h equals 1; 1 equals 1 or 2; m equals 1 or 2; n equals 0, 1 or 2; o equals an integer from 0 to 3, under the condition that n and o are equal to 0 at the same time. Values of group A are as given in claim 1 of the invention. Described also is a pharmaceutical composition having agonistic activity with respect to 7 serotonin (5-HT₄-receptors), which contains a compound of formula (1) and an agent which stimulates enterokinesis or improves functioning of the alimentary canal, which contains a compound of formula (1) as an active ingredient.

EFFECT: novel compounds are obtained and described, which have strong affinity towards 4 serotonin receptors, which are useful as an agent which stimulates enterokinesis or an agent which improves functioning of the alimentary canal.

28 cl, 233 ex, 29 tbl