RANK-L TARGETED AMINO ACID SEQUENCES AND POLYPEPTIDES CONTAINING THEM FOR TREATING BONE DISEASES AND DISORDERS Russian patent published in 2013 - IPC C07K16/22 C12N15/13 C12N15/63 A61K38/02 A61P19/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention provides RANK-L targeted amino acid sequences, as well as to a compound or a construct, and particularly, proteins and polypeptides which comprise or substantially consist of one or more of these amino acid sequences. The invention also discloses nucleic acids encoding such amino acid sequences and polypeptides; methods for preparing such amino acid sequences and polypeptides; host cells expressing or able for expressing such amino acid sequences or polypeptides. There are also disclosed compositions and particularly, pharmaceutical compositions for preventing and/or treating bone diseases and disorders, which include such amino acid sequences, polypeptides, nucleic acids and/or host cells. What is shown is a possibility to use the amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions for the preventive, therapeutic or diagnostic purposes.

EFFECT: polyvalent construct of the invention has a half-life in human serum from 12 hours to 19 days.

32 cl, 30 dwg, 24 tbl, 17 ex