FIELD: immunology; biotechnology.
SUBSTANCE: methods for the treatment of disease associated with tumor necrosis factor α (TNF-α) are proposed comprising administering to a subject in need thereof an effective amount of a polypeptide containing an immunoglobulin variable region that specifically binds to a TNF-α epitope.α At the same time, the binding TNF-α polypeptide specifically binds an epitope of TNF-α with KD less than 500 nM, has an EC50 value in a cellular assay using KYM cells that is better than 5 nM.
EFFECT: also the use of the epitope TNF-α for the selection or production of a polypeptide that is intended for use in a method and pharmaceutical composition for the treatment of a disease associated with TNF-α is proposed.
46 cl, 62 dwg, 50 tbl, 65 ex
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