ALBUMIN VARIANTS Russian patent published in 2018 - IPC C07K14/765 C07K19/00 C12P21/02 C12N15/62 C12N15/81 C12N5/10 A61K38/38 A61P43/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to variants of a parent albumin, which can be used in medicine. Polypeptide is obtained, which is a variant of albumin or a fragment thereof, wherein the polypeptide comprises changes in two or more positions selected from positions: (a) 492 and 580; (b) 492 and 574; (c) 492 and 550; (d) 550 and 573; (e) 550 and 574; (f) 550 and 580 in SEQ ID NO: 2, and does not contain mutations E492G+K573P, E492G+K573A or E492G+N503K, as well as polypeptides fused thereto, polynucleotides encoding these variants, conjugates, associates and nanoparticles with same, compositions, vectors, host cells containing these polynucleotides, and methods for using these variants.

EFFECT: invention makes it possible to obtain albumin variants having a longer half-life in plasma and an increased affinity for binding to FcRn as compared to the parent albumin.

80 cl, 4 dwg, 27 tbl, 5 ex