FIELD: chemistry.
SUBSTANCE: present invention provides a novel form of of 3-(3-{4-[3-(b-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide 
(chem. 1) with improved storage stability. Since bis[3-(3-{4-[3-(b-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide]monosebacate has extremely excellent storage stability, it can be used as a medicinal substance. Furthermore, it shows extremely good crystalline properties and can be purified by a conventional method, and therefore is suitable for the industrial preparation.
EFFECT: high storage stability.
9 cl, 2 ex, 5 tbl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| PYRAZOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | 2013 |
|
RU2602739C2 |
| DERIVATIVES OF GLUCOPYRANOSYLOXYPYRAZOLE AND THEIR USING IN MEDICINAL AGENTS | 2001 |
|
RU2317302C2 |
| PYRAZOLE DERIVATIEVES, MEDICAL COMPOSITIONS, CONTAINING SAID DERIVATIVES, THEIR APPLICATION IN MEDICINE AND INTERMEDIATE COMPOUNDS FOR THEIR OBTAINING | 2003 |
|
RU2356906C2 |
| PYRAZOL DERIVATIVES, MEDICAL COMPOSITIONS, CONTAINING THEM, THEIR APPLICATION IN MEDICINE AND INTERMEDIATE COMPOUNDS FOR THEIR PRODUCTION | 2003 |
|
RU2369613C2 |
| METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING POSTPRANDIAL HYPERGLYCEMIA ACCOMPANYING TYPE II DIABETES MELLITUS BY ADMINISTERING THROUGH ORAL MUCOSA | 2010 |
|
RU2543635C2 |
| PANCREATIC DIABETES DRUG | 2004 |
|
RU2358738C2 |
| PHARMACEUTICAL COMPOSITIONS | 2010 |
|
RU2532330C2 |
| COMBINATION FOR TREATMENT OF DIABETES AND COMPLICATIONS THEREOF | 2011 |
|
RU2451506C1 |
| PHARMACEUTICAL COMBINATION CONTAINING SGLT2 INHIBITOR | 2008 |
|
RU2489151C2 |
| NEW GLUCITOL DERIVATIVE, PRODRUG AND SALT AND THERAPEUTIC AGENT CONTAINING THEM FOR DIABETES TREATMENT | 2005 |
|
RU2386631C2 |
