FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel derivatives of glucopyranosyloxypyrazole of the general formula: 
wherein R means hydrogen atom, lower alkyl, acyl, alkoxycarbonyl, acyloxymethyl or alkoxycarbonyloxymethyl; one of Q and T represents a group of the general formula: 
wherein P means hydrogen atom, lower acyl or alkoxycarbonyl but other radical means lower alkyl or halogen(lower alkyl); R2 means hydrogen atom, lower alkyl, alkoxy-, alkylthio-group, halogen(lower)alkyl) or halogen atom under condition that P doesn't represent hydrogen atom when R means hydrogen atom or lower alkyl. Also, invention relates to pharmaceutically acceptable salts of these compounds, pharmaceutical compositions used for prophylaxis of renal glucose re-absorption and eliciting the inhibitory activity with respect to human SGLT2, pharmaceutical combinations that are used for prophylaxis or treatment of diseases associated with hyperglycemia.
EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.
36 cl, 1 dwg, 6 tbl, 48 ex
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