METHODS OF OBTAINING ARIPIPRAZOLE SUSPENSION AND LYOPHILYSED COMPOSITION Russian patent published in 2013 - IPC A61K9/10 A61K9/19 A61K31/496 A61K47/38 A61P25/18

Abstract RU 2483711 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to method of obtaining aripiprazole suspension. Method includes the following stages: (a) combining aripiprazole mass and carrier with formation of primary suspension; (b) first refining of primary suspension with obtaining secondary suspension using apparatus for refining with large shearing force, dispersant, in which shearing force is applied for material processing, or high-pressure homogeniser; and (c) second refining of secondary suspension with obtaining final sterile suspension by high-pressure homogeniser. Claimed composition also relates to methods of obtaining lyophilysed composition from aripiprazole suspension.

EFFECT: claimed invention provides possibility of obtaining aripiprazole suspension with the average size of particles from 1 to 10 mcm, without necessity to use special crystallisation technologies for obtaining initial aripiprazole mass and without application of vacuum mixing at the stage of combining aripiprazole mass and carrier.

33 cl, 13 tbl, 15 ex

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RU 2 483 711 C2

Authors

Khiraoka Shogo

Matsuda Takakuni

Khatanaka Junichi

Dates

2013-06-10—Published

2008-07-30—Filed