FIELD: chemistry.
SUBSTANCE: invention relates to novel 5-halogen-substituted oxindole derivatives of formula I: 
, where: R1 denotes hydrogen, methoxy or ethoxy group; R2 denotes hydrogen or a methoxy group; R3 denotes hydrogen, methyl, ethyl, n-propyl or isopropyl; R4 denotes an ethoxy or isopropoxy group; R5 denotes H or methyl; R6 denotes Cl or F; X1 denotes O, NH or CH2; X2 and X3 denotes N or CH under the condition that X2 and X3 do not denote N at the same time; as well as pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions for treating and/or preventing vasopressin-dependent diseases, which contain derivatives of formula I, and use thereof in treating vasopressin-dependent diseases.
EFFECT: high efficiency of using said compounds.
25 cl, 8 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES | 2008 |
|
RU2487872C2 |
| SUBSTITUTED OXYDOL DERIVATIVES AND USE THEREOF AS VASOPRESSIN RECEPTOR LIGANDS | 2007 |
|
RU2461556C2 |
| ROUTES OF APPLICATION OF PHOSPHODIESTERASE INHIBITORS | 2020 |
|
RU2795503C2 |
| N2-(2-PHENYL)-PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE DERIVATIVES AND USE THEREOF AS MPS1 INHIBITOR | 2015 |
|
RU2693460C2 |
| AZAANTRACYCLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1996 |
|
RU2159245C2 |
| WATER-SOLUBLE ANALOGUES CC-1065 AND THEIR CONJUGATES | 2007 |
|
RU2489423C2 |
| MACROHETEROCYCLIC NUCLEOSIDE DERIVATIVES AND ANALOGUES THEREOF, PRODUCTION AND USE | 2017 |
|
RU2731385C1 |
| 2,6-SUBSTUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | 2005 |
|
RU2417990C2 |
| HETEROCYCLIC DERIVATIVES AND USE THEREOF | 2015 |
|
RU2734390C2 |
| NEW ISOINDOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION INCLUDING THEREOF AND USE THEREOF | 2018 |
|
RU2728829C1 |
