FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to new substituted oxindole derivatives of formula (I) 
wherein X1 means -O-, -O-CH2-, -O-C(=O)-, -NR11-, -NR11-CH2- or -NR11-C(=O) -; X2 means a single bond, CO or CH2; X3 means N or CH; X4 means N or CH; A means phenylene or 6-merous heteroarylene with 1 or 2 nitrogen atoms as ring members with phenylene or heteroarylene being substituted by 1 or 2 residues R10; R1 and R3 independently mean hydrogen, C1-C3-alkyl, C1-C3-fluoroalkyl, C1-C3-alkoxy, C1-C3-fluoroalkoxy, halogen or CN; R2 means hydrogen or methoxy; at least one of residues R1, R2 and R3 mean hydrogen; R4 means hydrogen or C1-C4-alkyl; R5 means ethoxy, fluorinated ethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, or isopropoxy; R6 means hydrogen or methyl; R7 means hydrogen, I, Br, CI, F or CN; R8 means hydrogen, I, Br, CI, F or CN; R9 means C1-C3-alkyl or C1-C3-fluoroalkyl; R10 means C1-C3-alkyl, C1-C3-fluoroalkyl, C1-C3-alkoxy or C1-C3-fluoroalkoxy; R11 means hydrogen, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy or C1-C4-fluoroalkoxy; a means 0, 1 or 2; and m and n independently mean 1 or 2; as well as to pharmaceutically acceptable salts thereof. Furthermore, the invention refers to a pharmaceutical agent for treating and preventing the vasopressin-dependent diseases on the basis of the substituted oxindole derivatives, to the use of these compounds for preparing a drug, and moreover, to a method of treating the diseases.
EFFECT: there are prepared and described new compounds which may be effective in treating the vasopressin-dependent diseases.
38 cl, 82 ex, 1 tbl
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