METHOD OF OBTAINING BETA-LACTAM ANTIBIOTICS IN FORM OF POLYMER COMPLEX GEL WITH SILVER IONS Russian patent published in 2013 - IPC A61K9/00 A61K31/43 A61K31/166 A61P31/00 B82B3/00 

FIELD: medicine.

SUBSTANCE: invention relates to method of obtaining beta-lactam antibiotics in for of polymer complex gels with silver ions, which includes preparation of solutions of sodium salts of antibiotics of 0.1-1.0 mol/l concentration, solution of silver nitrate of 0.1-1.0 mol/l concentration, mixing observing ratio antibiotic:silver not less than 1 and not higher than 9, obtained solutions at temperature 10÷40°C with formation of dispersion of white colour, keeping dispersion without mixing until its decolouration with formation of colourless transparent gels, characterised by the fact that as antibiotic used are oxacillin derivatives, solutions of sodium salts of antibiotic contain 50-90 volume percent of water and 10-50 volume percent of organic solvent.

EFFECT: gel is thermally stable, ensures higher bactericidal and antibacterial activity and is prepared without additional polymer thickening agents.

11 dwg, 4 tbl, 3 ex