Show metadata Hide metadata

(19)

(11)

2 486 187

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/501(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2010114206/04, 2008-09-11

(24)

Start date

2008-09-11

(22)

Actual filing date

2008-09-11

(45)

Published

2013-06-27

(72)

Inventor

Kauert Marlon D.Marsh Kennan K.Liu Khuatsin'Li Dzae JongBekoni Maria G.Vetter Dzhil M.Blehk Lorens A.Kaster Tomas K.Chehn' Chzhao

(73)

Holder

Ehbbott Lehboretriz

OCTAHYDRO-PYRROLO[3,4-b]PYRROL N-OXIDES Russian patent published in 2013 - IPC C07D487/04 A61K31/501 A61P25/00

Abstract RU 2486187 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to octahydro-pyrrolo[3,4-b]pyrrol N-oxides or pharmaceutically acceptable salts thereof of general formula (I) wherein Z₁ represents N or CH. Octahydro-pyrrolo[3,4-b]pyrrol N-oxides of formula (I) are prodrugs of histamine-3 antagonists, and effective in treating conditions and disorders that can be prevented or relieved by H3-histamine receptor ligands. The present paper discloses N-oxide derivatives of octahydro-pyrrolo[3,4-b]pyrrol, the use of these compounds, compositions thereof and methods of treating a mammal having a condition or disorder wherein the H3-histamine receptor modulation has a therapeutic effect.

EFFECT: new compounds are presented.

11 cl, 2 tbl, 10 ex

Similar patents RU2486187C2

Title	Year	Author	Number
OCTAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES (VERSIONS), METHOD OF OBTAINING OCTAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES (VERSIONS), BASED ON THEM PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING DISEASE OR IMPAIRMENT OF STATE OF ORGANISM, SENSITIVE TO MODULATION OF HISTAMINE-3 RECEPTOR ACTIVITY	2007	Barns Dehvid M. Blehk Lorens A. Vittenberger Stiven Dzh. Grehg Robert Dzh. Kauehrt Marlon D. Kolachkovski Lorens Lou Sjaochun' San Minkhua Fiks Majkl G. Khajt Ehntoni R. Khenri Rodzher F. Chan Sou-Tszehn' Chzhan Dzheff G. Z. Chzhao Chehn' Chzhehn Go Chzhu Shejkh Akhmad I.	RU2492172C2
SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR TREATING VESTIBULAR DISORDERS	2009	Desmadril Zhil Shaber Kristyan	RU2589846C2
TETRAHYDROFURO(3,2-b)PYRROL-3-ONES AS CATHEPSIN K INHIBITORS	2007	Kvibell Martin Uotts Dzhon Pol	RU2456290C2
HETEROCYCLIC COMPOUNDS FOR TYROSINE KINASE 2 ACTIVITY MEDIATION	2020	Chen, Syanyan Pan, Yujchen	RU2826012C2
COMPOUNDS OF 1-CYANO-PYRROLIDINES AS USP30 INHIBITORS	2016	Dzhons Elison Kemp Mark Stokli Martin Gibson Karl Uitlok Gevin	RU2717238C2
2-R-6-R-5-ARYL-PYRROLE[3,4-c]CARBAZOLE-1,3(2H,6H)-DIONE SYNTHESIS METHOD	2009	Levchenko Pavel Viktorovich Shepelenko Evgenij Nikolaevich Makarova Nadezhda Ivanovna Rybalkin Vladimir Petrovich Metelitsa Anatolij Viktorovich Tolpygin Ivan Evgen'Evich Dubonosov Aleksandr Dmitrievich Bren' Vladimir Aleksandrovich Minkin Vladimir Isaakovich	RU2404983C1
MACROHETEROCYCLIC NUCLEOSIDE DERIVATIVES AND ANALOGUES THEREOF, PRODUCTION AND USE	2017	Ivashchenko Aleksandr Vasilevich Ivashchenko Andrej Aleksandrovich Savchuk Nikolaj Filippovich Mitkin Oleg Dmitrievich Ivashchenko Alena Aleksandrovna	RU2731385C1
DERIVATIVES OF 5-(2-IMIDAZOLINYLAMINO)-BENZ-IMIDAZOLE, PHARMACEUTICAL COMPOSITION	1998	Kapps Tomas Li Bogdan Sofi Li Nikolehjdes Nikolas Dzhilbert Sheri Ehnn Gazda Majkl Dobson Roj Li Martin Kruz Charl'Z Ehndrju Iii	RU2193562C2
ETHYL (3R,3AR,6AR*)-6-BENZYL-4-(DICYANOMETHYLENE)-5-OXO-2,3,6A-TRIPHENYLHEXAHYDRO-3AH-PYRROLO[3,2-D]ISOXAZOLE-3A-CARBOXYLATE, ANTIMICROBIAL	2022	Dmitriev Maksim Viktorovich Maslivets Andrei Nikolaevich Balandina Svetlana Iurevna Moroz Anna Andreevna	RU2784741C1
DERIVATIVES OF THIAZOLE POSSESSING ANTAGONISTIC, AGONISTIC OR PARTIALLY AGONISTIC CB-ACTIVITY	2003	Lange Josefus Kh.M. Krjusse Kornelis G. Kherremans Arnol'Dus Kh.J. Van Stejvenberg Kherman Kh. Dejksman Dzhessika A.R. Makriri Ehndrju K.	RU2301804C2

RU 2 486 187 C2

Authors

Kauert Marlon D.

Marsh Kennan K.

Liu Khuatsin'

Li Dzae Jong

Bekoni Maria G.

Vetter Dzhil M.

Blehk Lorens A.

Kaster Tomas K.

Chehn' Chzhao

Dates

2013-06-27—Published

2008-09-11—Filed