RECOVERED IP-10 ANTIBODY, IMMUNOCONJUGATE AND BIOSPECIFIC MOLECULE THEREOF, COMPOSITIONS THEREOF, METHOD OF TREATING (VERSIONS), CODING MOLECULE OF NUCLEIC ACID, RELATIVE EXPRESSION VECTOR, HOST CELL AND HYBRIDOMA Russian patent published in 2013 - IPC C07K16/18 C07K16/24 C07K16/46 C07K19/00 C12N15/13 C12N15/63 A61K39/395 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: presented invention refers to immunology. There are presented versions of recovered monoclonal antibodies and an antigen-binding portion thereof specific to human IP-10. There are described: an immunoconjugate, bispecific molecule thereof, as well as versions of a composition of the antibody, immunoconjugate or bispecific molecule - for treating autoimmune and inflammatory diseases. There are also disclosed: a coding nucleic acid, an expression vector thereof and a host cell carrying this vector to produce the antibody. What is described is using the antibody or antigen-binding portion thereof for preparing a medicine for treating: either a viral or bacterial infection entailing undesired IP-10 activity, or autoimmune and inflammatory diseases caused by undesired IP-10 activity. What is presented is a hybridoma producing the antibody, derived from a transgenic mouse splenocyte cross-linked to an immortalised cell.

EFFECT: use of the invention provides the novel antibodies that can be find application in medicine to treat a variety of diseases associated with IP-10 activity.

22 cl, 30 dwg, 9 tbl, 8 ex