INTERFERON ALPHA 1 RECEPTOR ANTIBODIES AND USE THEREOF Russian patent published in 2016 - IPC C07K16/28 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and represents a extracted monoclonal antibody or its antigen-binding site, which specifically binds human interferon alpha 1 receptor (IFNAR-1), containing heavy chain variable region CDR1, which contains SEQ ID NO: 4 with conservative modifications in sequence; heavy chain variable region CDR2, which contains SEQ ID NO: 8 with conservative modifications in sequence; heavy chain variable region CDR3, which contains SEQ ID NO: 12 with conservative modifications in sequence; light chain variable region CDR1, which contains SEQ ID NO: 16 with conservative modifications in sequence; light chain variable region CDR2, which contains SEQ ID NO: 20 with conservative modifications in sequence; light chain variable region CDR3, which contains SEQ ID NO: 24 with conservative modifications in sequence. Invention also relates to composition for treating disease or disorder, mediated by interferon type I, which contains therapeutically effective amount of above antibody or its antigen-binding site and pharmaceutically acceptable carrier.

EFFECT: invention allows to expand range of products for treating disease or disorder, mediated by interferon type I.

23 cl, 11 dwg, 5 tbl, 9 ex