FIELD: medicine.
SUBSTANCE: claimed are versions of separated monoclonal antibody, specific to INNAR-1. Described are: bispecific molecule, immunoconjugate and compositions for treatment of IFNAR-1-mediated diseases and disorders based on monoclonal antibody. Also described are methods of inhibiting biological activity of type I interferons, method of treating diseases and disorders, mediated by type I interferon with application of antibody. Claimed are nucleic acid, which codes antibody, vector for antibody expression, cell, transformed by vector, as well as method of obtaining antibodies and antibody-producing hybridoma.
EFFECT: application of invention provides novel IFNAR-1 inhibiting antibodies, which block IFNAR-1 and bind its other epitope, in comparison with known antibody 64G12.
29 cl, 15 dwg, 6 tbl, 9 ex
| Title |
Year |
Author |
Number |
| INTERFERON ALPHA 1 RECEPTOR ANTIBODIES AND USE THEREOF |
2005 |
- Kardarelli Zhozefin M.
- Vitte Elison
- Srinivasan Mokhan
|
RU2600884C2 |
| ANTI-IFNAR1 ANTIBODIES WITH LOWER LIGAND Fc AFFINITY |
2009 |
- Antoni Kojl
- Piter Kiner
- Kherren Vu
- Rikardo Chibotti
|
RU2556125C2 |
| RECOVERED PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) ANTIBODY AND METHOD OF INHIBITION OF PSMA-EXPRESSING CELL GROWTH |
2006 |
- Albaniz Dzhenni
- Kardarelli Dzhozefin M.
- Pehssmor Dehvid B.
- Chzhu Lej
|
RU2421466C2 |
| HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED DEATH 1 (PD-1) PROTEIN AND CANCER TREATMENT METHOD USING ANTI-PD-1-ANTIBODIES SEPARATELY OR COMBINED WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2013 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanyuj
- Selbi Mark Dzh.
- Chen Bin
- Kardarelli Zhozefin M.
|
RU2599417C2 |
| HUMAN MONOCLONAL ANTIBODIES TO THE PROTEIN OF PROGRAMMED DEATH 1 (PD-1) AND METHODS OF TREATING CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2016 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanyuj
- Selbi Mark Dzh.
- Chen Bin
- Kardarelli Zhozefin M.
|
RU2732924C2 |
| HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR PROGRAMMED CELL DEATH 1 (PD1) PROTEIN AND METHODS OF TREATING CANCER WITH USING ANTI-PD1 ANTIBODIES EITHER INDIVIDUALLY, OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2006 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanjuj
- Selbi Mark Dzh.
- Chehn' Bin
- Kardarelli Zhozefin M.
- Khuan Khajchun'
|
RU2494107C2 |
| HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED DEATH 1 (PD-1) PROTEIN AND CANCER TREATMENT METHOD USING ANTI-PD-1-ANTIBODIES SEPARATELY OR COMBINED WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2006 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanjuj
- Selbi Mark Dzh.
- Chehn' Bin
- Kardarelli Zhozefin M.
|
RU2406760C2 |
| ISOLATED ANTI-CD30 ANTIBODY (VERSIONS); HOST CELL, METHOD OF OBTAINING CHIMERIC OR HUMANISED VERSION OF ANTI-CD30 ANTIBODIES (VERSIONS), METHOD OF INHIBITING GROWTH OF CELLS CD30+ AND METHOD OF INHIBITING GROWTH OF TUMOUR CELLS EXPRESSING CD30 |
2006 |
- Blehk Amelija Nehnsi
- Kardarelli Dzhozefin M.
|
RU2492186C2 |
| BISPECIFIC ANTIBODY |
2020 |
- Shibayama, Shiro
- Tezuka, Tomoya
- Throsby, Mark
- De Kruif, Cornelis Adriaan
- Van Loo, Pieter Fokko
- Klooster, Rinse
- Roovers, Robertus Cornelis
|
RU2814713C2 |
| ALPHA5-BETA 1 ANTIBODIES AND USING THEM |
2009 |
- Bender Stiven Li
- Kasperson Dzheral'D Frajes
- Khu-Lou, Dana Dan
- Tszjan Sin'
- Li Gan
- Nort Majkl Ajdan
- Van Tszjan'In
- Uikman Grant
- Brams Peter
- Khuan Khajchun'
- Devo Bridzhit
- Chehn' Khajbin'
- Tanamachi Don M.
- Toj Kristofer
- Jan Lan'
- Spraul Tim U.
- Jamanaka Mark
|
RU2528736C2 |
