FIELD: biotechnology.
SUBSTANCE: method of batch crystallisation is provided for crystallising the antibody against hTNFα, comprising combining an aqueous solution of the antibody, salt of inorganic phosphate and acetate buffer, and incubating the resulting mixture. The crystalline antibody is considered, in particular the antibody D2E7 obtained by the method according to the invention, the pharmaceutical compositions including injectable liquid compositions comprising the antibody crystal, the crystal suspension, and also the methods of treatment the hTNFα-related disorder connected with, and application of the antibody crystals for obtaining the pharmaceutical composition for treatment such diseases.
EFFECT: invention can be additionally used in treatment of hTNFα-related diseases.
29 cl, 47 ex, 3 tbl, 7 dwg
| Title | Year | Author | Number |
|---|---|---|---|
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|
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| IMPROVED HIGH-CONCENTRATED LIQUID PREPARATIONS OF ANTIBODIES AGAINST TNF-ALPHA | 2011 |
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