METHOD FOR OBTAINING N-[2-(MORPHOLIN-4-YL)ETHYL]-4-CHLOROBENZAMIDE (VERSIONS) Russian patent published in 2015 - IPC C07D295/13 A61K31/5375 A61P25/24 

Abstract RU 2570898 C2

FIELD: chemistry.

SUBSTANCE: invention relates to method for obtaining N-[2-(morpholin-4yl)ethyl]-4-chlorobenzamide of formula I , which is obtained by opening 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole of formula II with morpholine with catalysis with protonic acids with heating in autoclave or under atmospheric pressure in absence of solvent at temperature from 120 to 200°C with output to 90%, or is obtained in two stages: first, as a result of condensation of 4-chlorobenzonitrile with 2-aminoethane in presence of Lewis acids or protonic acids in weakly polar aprotic solvents with heating from 120 to 200°C obtained is technical 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole II, which is after that opened with morpholine in catalysis with protonic acids with heating under atmospheric or higher pressure in absence of solvent at temperature from 120 to 200°C.

EFFECT: obtaining novel compounds.

2 cl, 5 ex

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RU 2 570 898 C2

Authors

Popkov Sergej Vladimirovich

Skvortsova Marija Nikolaevna

Bakhtin Pavel Andreevich

Dates

2015-12-20Published

2014-03-27Filed