FIELD: medicine.
SUBSTANCE: present invention relates to immunology. Antibody and a fragment thereof capable of binding to the epidermal growth factor receptor (EGFR) and containing hypervariable regions from the panitumumab antibody and the constant region of human IgG1 are provided. Also presented are: a nucleic acid molecule and a combination of nucleic acid molecules encoding antibody or fragment thereof; immunoconjugate and a pharmaceutical composition for treating or preventing diseases or disorders associated with abnormal EGFR expression. In addition, the use of antibody, a fragment thereof, a nucleic acid molecule, a combination of such molecules, immunoconjugate and a pharmaceutical composition in the manufacture of medicaments is discussed.
EFFECT: antibody as per present invention has optimal affinity for EGFR, improved biological and antitumor activity, and can therefore be used in cancer therapy.
14 cl, 5 dwg, 4 ex
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