STABILISED AMORPHOUS FORMS OF IMANITIB MESYLATE Russian patent published in 2013 - IPC A61K31/506 A61K47/40 A61K47/00 A61K9/16 A61K9/48 A61P35/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is disclosed is a pharmaceutical formulation containing an active agent stabilising an amorphous form of imatinib mesylate, and amorphous imatinib mesylate. The active agent is selected from solid dispersions, and dry co-milling products with excipients. The solid dispersion contains an additional excipient selected from cellulose derivatives, polyvinylpyrrolidone, polyethylene glycols of various molecular weight, polyethylene/polypropylene/polyethylene oxide block copolymers, and polymethacrylates. The excipients for dry co-milling selected from polyvinylpyrrolidone, cellulose derivatives, alkaline earth silicates, and silicon dioxide.

EFFECT: active agents stabilise imatinib mesylate in the amorphous form.

3 cl, 4 tbl, 5 ex