FIELD: pharmaceutics.
SUBSTANCE: invention relates to a compound of general formula (I), where R1 and R4 are independently selected from the group consisting of hydrogen and (C1-C4)alkyl; R2 and R3 are independently selected from the group consisting of hydrogen and (C1-C4)alkyl; n = 0, 1 or 2; and when n is 0, R4 is absent; Q is selected from the group consisting of -O-C(O)-R 5 and -O-C(O)-(C1-C6)alkyl-R5; R5 is selected from a group consisting of (5–6)-membered heteroaryl containing 1–3 heteroatoms, selected from N, O or S, benzimidazolyl and (4–6)-membered heterocycloalkyl containing 1 heteroatom selected from N, O, S or S(O)2, where said heteroaryl, benzimidazolyl and heterocycloalkyl are optionally substituted with one or more substituents independently selected from R6; R6 consists of hydroxyl, (C1-C4)alkyl, (C1-C4)alkyloxy, -ORx, -C(O)NRaRb, -C(O)ORa, -C(O)Ra, (C3-C4)cycloalkyl; Rx is (C1-C4)alkyl; Ra and Rb independently represent (C1-C4)alkyl; or a pharmaceutically acceptable salt thereof. Invention also relates to a pharmaceutical composition for inhibiting phosphodiesterase 4 (PDE4) based on said compounds.
EFFECT: obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating or relieving inflammatory skin diseases or conditions.
19 cl, 5 tbl, 115 ex
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