MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE Russian patent published in 2012 - IPC C07D401/14 C07D403/12 C07D403/14 A61K31/4164 A61K31/44 A61P35/00 A61P29/00 A61P25/28 A61P11/06 

FIELD: chemistry.

SUBSTANCE: present invention relates to heterocyclic compounds of formula (I), where R¹ represents C_1-6 alkyl, optionally substituted with hydroxy, monocyclic C_3-8 cycloaliphatic radical, optionally substituted with hydroxy, or phenyl; R² represents H, C_1-6 alkyl, optionally substituted with hydroxy or morpholine, monocyclic C_3-8 cycloaliphatic radical, optionally substituted with a hydroxy group or a heterocycloaliphatic radical, where the heterocycloaliphatic radical is piperidine, pyrrolidine or morpholine; each of a, a', b and c independently represents N or C(R³); each of R³, R⁵ and R⁶ independently represents H, halogen, phenyl, substituted with one substitute selected from methoxy methyl, amino, methoxy or trifluoromethoxy, or heteroaryl substituted with alkyl, hydroxy or alkoxy; R⁴ represents H; K represents -N(R^X')-; J represents a bond, -O, alkylene, -C(O)-, -C(O)-O-, or -C(O)-N(R^x')-; R^X' represents H; n equals 0; and under the condition that if R¹ represents an unsubstituted alkyl, J represents -O-, then R² represents H. The invention also relates to a pharmaceutical composition based on a compound of formula (I).

EFFECT: obtaining novel heterocyclic compounds, useful as modulators of interleukin receptor-associated kinase IRAK.

20 cl, 18 ex