SUBSTITUTE NICOTINE-AMIDE COMPOUNDS AND THEIR APPLICATION IN MEDICINAL AGENTS Russian patent published in 2013 - IPC C07D213/82 C07D401/12 C07D405/12 C07D409/12 A61K31/33 A61P25/06 

FIELD: biotechnologies.

SUBSTANCE: invention relates to substitute nicotine-amide compounds of general formula , where n=0, 1 or 2, p=0 or 1, q=0 or 1, R¹ is aryl or heteroaryl or heterocyclyl, non-substitute or mono- or polysubstitute; C_1-6-alkyl, C_3-10-cycloalkyl, non-substitute or mono- or polysubstitute; R² is H or C_1-6-alkyl; R³ is aryl or pyridyl, non-substitute or mono- or polysubstitute; C_1-6-alkyl or C_3-10-cycloalkyl, in each case non-substitute or mono- or polysubstitute; R⁴, R⁵, R⁶ and R⁷ independently from each other represent H; C_1-6-alkyl; R⁸, R⁹ and R¹⁰ independently from each other represent H, F, Cl, Br, CF₃, C_1-6-alkyl; where "substitute alkyl", "substitute heterocyclyl" and "substitute cycloalkyl" stands for substitution of hydrogen radical for F, Cl, Br, I, C_1-6-alkyl, SH, S-C_1-6-alkyl, O-C_1-6-alkyl, O-C₁-benzyl, -OH, O-C_1-6-alkyl-OH, phenyl, phenoxy, morpholynyl or benzyl; and "substitute aryl" and "substitute heteroaryl stands for single or multiple substitution of one or several atoms of circular system for F, Cl, Br, I, SH, S-C_1-6-alkyl, OH, O-C_1-6-alkyl, O-C_1-6aryl-OH, CH₂SO₂-phenyl, OCF₃, SCF₃, CF₃, , , C_1-6-alkyl, morpholynyl, phenoxy, phenyl or pyrazolyl; provided that if R³ is 3-trifluoromethylphenyl or 4-trifluoromethyl-2-pyridyl, R², R⁴ and R⁵ are H, and n is 0, then R¹ is not 2-pyridyl or 2-thienyl; and if R³ is or methyl, R², R⁴ and R⁵ are H, and n is 0, then R¹ is not 2-thienyl; in the form of racemate; enantiomers, diastereisomers, mixtures of enantiomers or diastereisomers or a separate enantiomer or diastereisomer; bases and/or salts of physiologically acceptable acids. Besides, the invention relates to a pain killer containing specified compounds and to application of the specified compounds for preparation of medicinal agents.

EFFECT: new compounds were produced and described, which may find their application in pain treatment.

13 cl, 150 ex, 8 tbl, 1 dwg