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2 553 392

(13)

(51)

IPC

C07D231/12(2006-01-01)

C07D249/08(2006-01-01)

A61K31/415(2006-01-01)

A61K31/4196(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2011149360/04, 2010-05-06

(24)

Start date

2010-05-06

(22)

Actual filing date

2010-05-06

(45)

Published

2015-06-10

(72)

Inventor

Robert FrankGregor BarenbergTomas KristofKlaus ShineZhan De-VriNil'S DamannSven FrormannBernkhard LeshChzhiu LiEnsu KimMensop Kim

(73)

Holder

Grjunental' Gmbkh

SUBSTITUTED PHENYLUREAS AND PHENYLAMIDES AS LIGANDS OF VANILLOID RECEPTORS Russian patent published in 2015 - IPC C07D231/12 C07D249/08 A61K31/415 A61K31/4196 A61P29/00

Abstract RU 2553392 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to substituted phenylureas and phenylamides of formula in which X stands for CR³ or N, where R³ stands for H; C_1-10alkyl, saturated or unsaturated, branched or non-branched, non-substituted; or CF₃; A stands for N or CR^5b; R¹ stands for substructure , which has the formula, given below. The other radicals and symbols have the values, given in the invention formula. The invention also relates to methods of obtaining formula (If) compounds, to pharmaceutical compositions, containing the said compounds, as well as to the application of the said compositions for the preparation of the pharmaceutical compositions.

EFFECT: formula (If) compounds possess activity with respect to the vanilloid receptor of I subtype (receptor VR1/TRPV1).

7 cl, 1 tbl, 147 ex

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RU 2 553 392 C2

Authors

Robert Frank

Gregor Barenberg

Tomas Kristof

Klaus Shine

Zhan De-Vri

Nil'S Damann

Sven Frormann

Bernkhard Lesh

Chzhiu Li

Ensu Kim

Mensop Kim

Dates

2015-06-10—Published

2010-05-06—Filed