Show metadata Hide metadata

(19)

(11)

2 490 260

(13)

(51)

IPC

C07D221/12(2006-01-01)

C07D401/06(2006-01-01)

A61K31/473(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2010143857/04, 2009-03-26

(24)

Start date

2009-03-26

(22)

Actual filing date

2009-03-26

(45)

Published

2013-08-20

(72)

Inventor

Anzhibo Patrik ReneMevellek Lorans AnnRu BrjunoStork P'Er-AnriMejer KristofVialard Khorkhe Ehduardo

(73)

Holder

Janssen Farmatsevtika Nv

TETRAHYDROPHENANTRIDIONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP INHIBITORS AND TUBULIN POLYMERISATION INHIBITORS Russian patent published in 2013 - IPC C07D221/12 C07D401/06 A61K31/473 A61P35/00

Abstract RU 2490260 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula

using them as tubulin polymerisation inhibitors and PARP inhibitors, and also as an ingredient of pharmaceutical compositions containing the above compounds of formula (I), wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷and Y have the values specified in the patent claim.

EFFECT: preparing intermediate compounds for preparing the compounds of formula (I) and a method for preparing the intermediate compounds.

16 cl, 3 tbl, 40 ex

Similar patents RU2490260C2

Title	Year	Author	Number
MDM2 AND P53 INTERACTION INHIBITORS	2007	Lakramp Zhan Fernan Arman Mejer Kristof Skhunt'Es Brjuno Lardo Delfin Ivonn Rajmond Ponsele Alen Filipp Van Khejfte Ljuk	RU2436784C2
PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS	2008	Branka Danila Dessole Gabriehlla Ferrin'O Federika Dzhouns Filip Kintsel' Olaf Lillini Samuehle Mural'Ja Ehster Peskatore Dzhovanna Shul'Tts-Fademrekht Karsten	RU2490265C2
SUBSTITUTED QUINAZINE DERIVATIVES AS FGFR-KINASE INHIBITORS FOR TREATMENT OF CANCER	2011	Saksti Gordon Mjurrej Kristofer Uilljam Berdini Valerio Bezong Gilbert Ebaj Khamlett Kristofer Charlz Frederik Vudkhed Stiven Dzhon Lini Jannik Eme Eddi Anzhibo Patrik Rene	RU2602233C2
COMPOUNDS AND COMPOSITIONS AS CANAL ACTIVATING PROTEASE INHIBITORS	2007	Talli Dejvid S. Chatterdzhi Arnab K. Petrassi Khank Majkl Dzhejms Bursulaja Badri Spraggon Glen	RU2419625C2
ANTI-CANCER BENZOPYRAZINES ACTING THROUGH FGFR-KINASES INHIBITION	2012	Vudkhed Stiven Dzhon Myurrej Kristofer Uillyam Berdini Valerio Saksti Gordon Bezong Gilbert Ebaj Merpul Liven Keroll Olive Aleksis Zhorzh Ponsele Virzhini Sofi	RU2639863C2
POLY(ADP-RIBOSE)POLYMERASE INHIBITOR PRODUCTION METHOD	2005	Ma Chunrong Najjar Naresh Stankovits Nebojsja Slobodan	RU2344138C2
MDM2 AND P53 INTERACTION INHIBITORS	2008	Ponsele Virzhini Sofi Kupa Sofi Stork P'Er-Anri Skhunt'Es Brjuno	RU2477724C2
SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS	2012	Fleri Melissa Gendron Roland Khjuz Adam D.	RU2604522C2
PTERIDINES AS FGFR INHIBITORS	2013	Saksti Gordon Khamlett Kristofer Charlz Frederik Berdini Valerio Myurrej Kristofer Uillyam Anzhibo Patrik Rene Keroll Olive Aleksis Zhorzh Ponsele Virzhini Sofi	RU2702906C2
IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES	2009	Uill'Jams Brajan Dzhon Berdini Valerio Karr Marija Gratsija Kongriv Majlz Stjuart Frederikson Martin Griffits-Dzhounz Sharlott Mehri Khamlett Kristofer Charl'Z Frederik Mehdin Ehndrju Mjurrej Kristofer Uill'Jam Benning Radzhip Kaur Saksti Gordon Vikerstaff Ehmma Vudkhehd Ehndrju Dzhejms Vudkhehd Stiven Dzhon Frejn Ehddi Zhan Ehdgar Govarts Tom Kornelis Khortense Anzhibo Patrik Rene	RU2518089C2

RU 2 490 260 C2

Authors

Anzhibo Patrik Rene

Mevellek Lorans Ann

Ru Brjuno

Stork P'Er-Anri

Mejer Kristof

Vialard Khorkhe Ehduardo

Dates

2013-08-20—Published

2009-03-26—Filed