Show metadata Hide metadata

(19)

(11)

2 490 268

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/407(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2011145513/04, 2011-11-10

(24)

Start date

2011-11-10

(22)

Actual filing date

2011-11-10

(45)

Published

2013-08-20

(72)

Inventor

Bachurin Sergej OlegovichUstjugov Aleksej Anatol'EvichNinkina Natal'Ja NikolaevnaSokolov Vladimir BorisovichAksinenko Aleksej Jur'EvichShelkovnikova Tat'Jana AleksandrovnaBolkunov Aleksej Viktorovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Fiziologicheski Aktivnykh Veshchestv Rossijskoj Akademii Nauk Ran)

FLUORINE-CONTAINING SUBSTITUTED 5-[2-(PYRID-3-YL)-ETHYL]-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-b]INDOLE HYDROCHLORIDES AS AGENTS DECREASING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, BASED PHARMACEUTICAL PREPARATION AND METHOD OF USING IT Russian patent published in 2013 - IPC C07D471/04 A61K31/407 A61P25/00

Abstract RU 2490268 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to organic chemistry, namely to new fluorine-containing substituted 5-[2-(pyrid-3-yl)-ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochlorides of general formula , R₁ = H, (C₁-C₆) alkyl; R₂, R₃, R₄, R₅ = H, F, Cl, Br, (C₁-C₆) alkyl, (C₁-C₆) alkoxy; R₆ = F, CF₃. Also, the invention refers to pharmaceutical compositions based on the compound of formula (I), and to a method of decreasing uncontrolled protein aggregation in the nervous system involving administering the pharmaceutical preparation containing an effective amount of the compound of formula (I) to a patient.

EFFECT: new derived 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochlorides effective for decreasing uncontrolled protein aggregation in the nervous system are produced.

3 cl, 12 dwg, 2 tbl, 14 ex

Similar patents RU2490268C2

Title	Year	Author	Number
PHENOTHIAZINE-CONTAINING 1,2,3,4-TETRAHYDROPYRIDO[4,3-b]INDOLE DERIVATIVES AS AGENT FOR REDUCING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, METHODS FOR PRODUCTION THEREOF, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF REDUCING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM	2013	Bachurin Sergej Olegovich Sokolov Vladimir Borisovich Aksinenko Aleksej Jur'Evich Makhaeva Galina Fajvelevna Grigor'Ev Vladimir Viktorovich Ninkina Natal'Ja Nikolaevna Kukharskij Mikhail Sergeevich	RU2529899C1
LUMINOPHORES BASED ON 2,6-BIS(AMINOVINYL)-4-METHYLENE-1,4-DIHYDROPYRIDINE AND METHOD FOR PRODUCTION THEREOF	2023	Obydennov Dmitrii Lvovich Simbirtseva Alena Evgenevna Sosnovskikh Viacheslav Iakovlevich	RU2824353C1
TRANS-2-DECENOIC ACID DERIVATIVE AND MEDICINAL AGENT CONTAINING SAME	2013	Iinuma Munekazu Furukava Soei Naiki Mitsuru Matsumoto Tomonori Khigasiura Kunikhiko	RU2602810C2
SUBSTITUTED INDOL-5-OL DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF	2013	Tao Chunlin Van Tsinvej Kho Devid Polat Tulaj Nallan Laksman Soon-Shiong Patrik	RU2674249C2
PENTACYCLIC COMPOUND	2018	Okhasi, Josiaki Norimine, Josikhiko Khosikava, Tamaki Josida, Yu Kobayasi, Josikhisa Sato, Nobukhiro Khagivara Kodzi	RU2754557C1
6,7-MODIFIED PACLITAXELS AND INTERMEDIATE COMPOUNDS	1993	Shu-Kh'Ju Chen Vittorio Farina Gregori Rot Dzhon Kehdou	RU2125998C1
METHOD FOR SYNTHESIS OF BENZO[7,8]AZONINO[5,4-b]INDOLE, 7,9-ETHENO-AZECINO [5,4-b]INDOLE AND 7,9-ETHANO-AZECINO[5,4-b]INDOLE DERIVATIVES	2009	Varlamov Aleksej Vasil'Evich Borisova Tat'Jana Nikolaevna Voskresenskij Leonid Gennad'Evich Titov Aleksandr Anatol'Evich	RU2397984C1
NOVEL PYRAZOLE DERIVATIVES	2013	Sugimoto Khatiro Okuda Mitiaki Nakayama Siniti Inoue Josikadzu Sakata Joko Fudzita Yuki Tokidzane Rie	RU2682679C2
THERAPEUTIC AGENTS AIMED AT SHORTENED PROTEINS OF ADENOMATOUS POLYPOSIS COLI (APC)	2014	Debrabander Dzhef Shej Dzherri V. Van Ventyan	RU2727516C2
HYDROXYPYRIDOXAZEPINES AS Nrf2 ACTIVATORS	2020	Elban, Mark Glogowski, Michal Pawel Koetting, Michael Clinton Lawhorn, Brian Griffin Matthews, Jay M. Patterson, Jaclyn Renee	RU2812931C2

RU 2 490 268 C2

Authors

Bachurin Sergej Olegovich

Ustjugov Aleksej Anatol'Evich

Ninkina Natal'Ja Nikolaevna

Sokolov Vladimir Borisovich

Aksinenko Aleksej Jur'Evich

Shelkovnikova Tat'Jana Aleksandrovna

Bolkunov Aleksej Viktorovich

Dates

2013-08-20—Published

2011-11-10—Filed