FIELD: organic chemistry. SUBSTANCE: invention relates to 6,7-modified paclitaxels of the formula (I)
where R1 is Rz where R2 means RO or R; R2 - radical of the formula W-Rx where W - a bond, C2-6-alkenediyl or -(CH2)t; t = 1-6; Rx - phenyl, furyl, thienyl or oxazolyl; R3 means -OCOR, -OR, OSO2R, -OCOO-(CH2)tR or -OCOOR; Rb and Rc taken together form a bond with carbon atoms to which they are bound; R and Ro - alkyl, alkenyl, C3-6-cycloalkyl or phenyl possibly substituted with 1-3 alkyls or halogen atoms. Compounds of the formula (I) show antitumor activity. EFFECT: improved method of synthesis, enhanced antitumor activity. 7 cl, 6 dwg, 1 tbl, 26 ex
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