FIELD: chemistry.
SUBSTANCE: invention relates to phenothiazine-containing 1,2,3,4-tetrahydropyrido[4,3-b]indole derivatives of general formula 1 
and hydrochlorides thereof as an agent for reducing uncontrolled protein aggregation in the nervous system, methods for production thereof, a pharmacological agent based thereon and a method of reducing uncontrolled protein aggregation in the nervous system. In general formula 1: R1=H, (C1-C6)alkyl; R2, R3, R4, R5=H, F, O, Br, (C1-C6)alkyl, (C1-C6)alkoxy, R6, R7= H, F, Cl, Br, (C1-C6)alkyl, (C1-C6)alkoxy, NH2, NHAlkyl, NAlkyl2, A=CH2CH2, CH=CHCH2, CH2CH2CH2, CH2CH[(C1-C6)alkyl]C(O), CH2CH2C(O)NHCH2CH2); CH2CH[((C1-C6)alkyl]C(O)N[(C1-C6))alkyl]CH2CH2), CH2CH(OH)CH2, CH2CH(OH)CH2NHCH2CH2, CH2CH(OH)CH2N[(C1-C6)alkyl]CH2CH2, CH2CHFCH2NHCH2CH2, CH2CHFCH2N[(C1-C6)alkyl]CH2CH2.
EFFECT: improved properties of derivatives.
9 cl, 2 tbl, 11 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF 1,2,3,4-TETRAHYDROPYRIDO[4,3-b]INDOLE-CONTAINING PHENOTHIAZINES AS INHIBITORS OF CHOLINESTERASES AND BLOCKERS OF SEROTONIN RECEPTORS 5-HT, METHODS OF OBTAINING THEIR CHLOROHYDRATES AND BASED ON THEM PHARMACEUTICAL PREPARATION | 2013 |
|
RU2530881C1 |
| FLUORINE-CONTAINING SUBSTITUTED 5-[2-(PYRID-3-YL)-ETHYL]-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-b]INDOLE HYDROCHLORIDES AS AGENTS DECREASING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, BASED PHARMACEUTICAL PREPARATION AND METHOD OF USING IT | 2011 |
|
RU2490268C2 |
| DERIVATIVES OF AZOLE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF ELICITING ACTIVITY WITH RESPECT TO SEROTONIN 5-HT- | 1995 |
|
RU2146256C1 |
| ADAMANTANE-CONTAINING INDOLES AND THEIR HYDROCHLORIDES WITH MICROTUBULES STABILIZING PROPERTY, METHODS OF THEIR PRODUCTION, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF TREATING AND PREVENTING DISEASES ASSOCIATED WITH MICROTUBULE SYSTEM DISORDERS | 2015 |
|
RU2608631C1 |
| DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT | 1995 |
|
RU2140417C1 |
| ISOXAZOLINES AND ISOXAZOLES, METHOD OF INHIBITION OF PLATELET AGGREGATION, PHARMACEUTICAL COMPOSITION INHIBITING PLATELET AGGREGATION | 1994 |
|
RU2149871C1 |
| DERIVATIVES OF TRIAZOLO[1,4]DIAZEPINE AND METHODS OF THEIR SYNTHESIS | 1989 |
|
RU2117670C1 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF PATIENT TREATMENT, INTERMEDIATE COMPOUND | 1993 |
|
RU2130453C1 |
| SUBSTITUTED PYRIMIDINETHIOALKYL OR ALKYLESTER COMPOUNDS AND METHOD OF INHIBITION OF VIRAL REVERSE TRANSCRIPTASE ACTIVITY | 1996 |
|
RU2167155C2 |
| COMPOUNDS TARGETING TAU PROTEIN AND RELATED USE THEREOF | 2017 |
|
RU2805523C2 |
