INHIBITORS OF FATTY ACID AMIDE HYDROLASE Russian patent published in 2013 - IPC C07F5/02 A61K31/69 A61P29/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical composition for treatment of disease, disorder or pathological state, mediated by fatty acid amide hydrolase (FAAH). Composition contains therapeutically efficient quantity of compound which has the following formula: or pharmaceutically acceptable form of said compound and pharmaceutically acceptable filling agent, where: Z¹ and Z² in each case independently represent hydroxy; n represents 1, 2, 3 or 4; m represents 1 or 2; X represents bond, O, S, NR³, CR⁴R⁵, OCR⁴R⁵, CR⁴R⁵O, SCR⁴R⁵, CR⁴R⁵S, NR³CR⁴R⁵ or CR⁴R⁵NR³; R¹ in each case independently represents halogen, alkyl, perhaloalkyl, alkoxy or trihaloalkoxy; R² in each case independently represents halogen, alkyl, perhaloalkyl, nitro, alkoxy, trihaloalkoxy, aryloxy, carboxy, amido, ester group or - NR⁴CO₂R⁵; or two R² at adjacent carbon atoms together form 5-7-membered possibly substituted ring, which contains from 0 to 3 heteroatoms, selected from group, which includes O; and each of R³, R⁴ and R⁵ in each case independently represents H, alkyl, ester group or amido. Also claimed are compounds, method of treatment, application of pharmaceutical composition, application of compounds and method of obtaining compound.

EFFECT: invention makes it possible to obtain pharmaceutical compositions, which represent efficient inhibitors of fatty acid amide hydrolases (FAAH).

37 cl, 4 tbl, 176 ex