FIELD: pharmaceutics.
SUBSTANCE: invention relates to specific compounds, which are substituted phenoxy- and benzyloxy-piperidine corresponding to the structural formula (I). The invention also relates to a method for producing compounds according to the invention and a pharmaceutical composition based on such compounds.
EFFECT: compounds according to the invention are intended for the use in the treatment or prevention of diseases related to P2X7 receptor activity.
5 cl, 1 dwg, 6 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED THIAZOLES OR OXAZOLES AS P2X7 RECEPTOR ANTAGONISTS | 2015 |
|
RU2701858C1 |
| N-(2-HYDROXYETHYL)-N-METHYL-4-(QUINOLIN-8-YL(1-(THIAZOL-4-YLMETHYL) PIPERIDIN-4-YLIDENE)METHYL)BENZAMIDE, METHOD FOR PREPARING AND APPLYING IT FOR TREATING PAIN, ANXIETY AND DEPRESSION | 2007 |
|
RU2454414C2 |
| HETEROCYCLIC ANTAGONISTS P2X7 | 2018 |
|
RU2768865C2 |
| NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-d]PYRIMIDINE-2-(3H)-AMINE DERIVATIVES AND USE THEREOF IN THERAPY | 2007 |
|
RU2437889C2 |
| NEW 5,7-DISUBSTITUTED [1,3]THIAZOLO-[4,5-d]PYRIMIDIN-2(3H)-ONE DERIVATIVES AND THEIR APPLICATION IN THERAPY | 2007 |
|
RU2441012C2 |
| N-[5-(AMINOSULPHONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MONOHYDRATE | 2012 |
|
RU2669388C1 |
| NEW CRYSTALLINE FORM OF 2-{3-[2-(1-{[3,5-BIS(DIFLUOROMETHYL)-1H-PYRAZOL-1-YL]ACETYL}PIPERIDIN-4-YL)-1,3-THIAZOL-4-YL]-4,5-DIHYDRO-1,2-OXAZOL-5-YL}-3-CHLOROPHENYLMETHANE SULPHONATE | 2014 |
|
RU2691948C2 |
| (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID | 2016 |
|
RU2726623C2 |
| MESYLATE N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MONOHYDRATE | 2012 |
|
RU2620604C2 |
| N-PHENYL(PIPERIDINE-2-YL)METHYL-BENZAMIDE DERIVATIVES, AND THEIR APPLICATION IN THERAPY | 2004 |
|
RU2351588C2 |
