FIELD: biotechnologies.
SUBSTANCE: immunostimulatory complex is described, which includes an RNA in the form of a complex with one or more oligonucleotides. Besides, the oligonucleotide has properties of peptide penetrating into a cell (CPP), contains from 8 to 15 amino acid remains and is characterised by the following general formula: (Arg)1(Lys)m(His)n(Orn)o(Xaa)x. At the same time the main number of remains is selected from Arg, Lys, His, Orn.
EFFECT: invention may be used for transfection of a cell, tissue or organism or for modulation, preferably induction or increasing immune response.
16 cl, 22 dwg, 11 ex
| Title |
Year |
Author |
Number |
| COMBINATION OF ANTI-CANCER RNA VACCINE AND PD-1 PATHWAY INHIBITOR AND ITS APPLICATION |
2014 |
- Fotin-Mlechek Mariola
- Kallen Karl-Jozef
- Probst Jokhen
|
RU2718988C2 |
| OBTAINING OF COMPLEXES OF NUCLEIC ACIDS AND CATIONIC COMPONENTS CROSS SEWED BY DISULFIDE BONDS INTENDED FOR TRANSFECTION AND IMMUNOSTIMULATION |
2011 |
- Baumkhof Patrik
- Foss Zenke
- Kramps Tomas
- Kallen Karl-Jozef
|
RU2575603C2 |
| DISULPHIDE-LINKED POLYETHYLENE GLYCOL/PEPTIDE CONJUGATES FOR NUCLEIC ACID TRANSFECTION |
2010 |
- Patrik Baumkhof
- Tomas Shlake
|
RU2552352C2 |
| METHOD FOR INCREASING THE EXPRESSION OF ENCODED RNA PROTEINS |
2014 |
|
RU2733424C2 |
| COMPOSITION FOR TREATING LUNG CANCER, FIRST NON-SMALL CELLS LUNG CANCER (NSCLC) |
2008 |
- Marijke Barner
- Jokhen Probst
- Tomas Lander
- Ingmar Gerr
|
RU2526510C2 |
| COMPOSITION CONTAINING COMPLEX (M)RNA AND FREE MRNA FOR IMPLEMENTING OR IMPROVING IMMUNOSTIMULATORY RESPONSE IN MAMMALS AND USING IT |
2009 |
- Mariola Fotin-Mlechek
- Zenke Foss
|
RU2545756C2 |
| ANTIGEN-BINDING PROTEIN RECOGNIZING PEPTIDE ORIGINATING FROM MAGE-A4 |
2018 |
- Siku, Khirosi
- Akakhori, Yasusi
- Kato, Yujya
- Miyakhara, Josikhiro
|
RU2777074C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING COMPLEX OF POLYMER CARRIER AND CARRIED SUBSTANCE AND AT LEAST ONE PROTEIN OR PEPTIDE ANTIGEN |
2013 |
- Baumkhof Patrik
- Kramps Tomas
- Foss Zenke
- Kallen Karl-Jozef
- Fotin-Mlechek Mariola
|
RU2617058C2 |
| COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX CONTAINING A CELL-PENETRATING PEPTIDE, A CARGO MOLECULE, AND A TLR PEPTIDE AGONIST, FOR APPLICATION IN MEDICINE |
2017 |
- Derouazi Madiha
- Belnoue Elodie
|
RU2769314C1 |
| HYBRID CARRIERS FOR DELIVERY OF NUCLEIC ACIDS |
2017 |
- Baumkhof, Patrik
- Tile-Zyus, Karolin
- Rejman, Joanna
|
RU2751001C2 |
