OBTAINING OF COMPLEXES OF NUCLEIC ACIDS AND CATIONIC COMPONENTS CROSS SEWED BY DISULFIDE BONDS INTENDED FOR TRANSFECTION AND IMMUNOSTIMULATION Russian patent published in 2016 - IPC C12N15/87 A61K39/39 A61K48/00 A61K47/48 A61K39/00 

Abstract RU 2575603 C2

FIELD: biotechnologies.

SUBSTANCE: complex contains the polymeric carrier formed by the cationic components which are cross sewed by disulfide bonds where the cationic components cross sewed by disulfide bonds are cationic peptides, and the named disulfide bonds are formed by the cysteine residues which are comprised by cationic peptides localized near the terminal ends of cationic peptides, and the cargo molecule which at least one one-chained molecule of RNA.

EFFECT: invention allows to perform efficient transfection of cells by nucleic acids both in vivo, and in vitro, and is intended for induction of congenital or adaptive immune response.

10 cl, 15 dwg, 1 tbl, 1 ex

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RU 2 575 603 C2

Authors

Baumkhof Patrik

Foss Zenke

Kramps Tomas

Kallen Karl-Jozef

Dates

2016-02-20Published

2011-07-25Filed