PYRROLIDINE DERIVATIVES Russian patent published in 2013 - IPC C07D207/09 C07D207/10 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to pyrrolidine derivatives of formula: where: each of R¹, R², R³, R⁴, R⁵ and R⁶ independently denotes H, C_1-10alkyl; R⁷ denotes C_1-10alkyl, a 5-6-member monocyclic aromatic heteroaryl, having one or two heteroatoms selected from N, S, optionally substituted with C_1-10alkyl; R denotes H, C_1-10alkyl; or R⁷ and R⁸, together with a N with which they are attached, form a 5-8-member monocyclic, saturated or unsaturated ring, optionally including a second hateroatom selected from N, S, O, optionally substituted with a halogen, CN, -OR', C_1-10alkyl, hydroxyC_1-10alkyl, C_1-10alkoxyC_1-10alkyl, -S(O)₂R', -C(O)OR', or form a 8-12-member bicyclic, saturated or unsaturated ring; R' denotes H, C_1-10alkyl; m and n are independently equal to 0, 1, 2 or 3; X denotes NR^a, R^a denotes H. The compounds are used in a method of inhibiting dipeptidyl peptidase IV.

EFFECT: obtaining pyrrolidine derivatives.

13 cl, 2 dwg, 1 tbl, 26 ex