5-(4-METHANESULPHONYL PHENYL)THIAZOLE DERIVATIVES FOR TREATING ACUTE AND CHRONIC INFLAMMATORY DISEASES Russian patent published in 2013 - IPC C07D277/24 A61K31/425 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to using the compounds of formula (I) wherein R₁ is specified in C₁-C₆ alkyl optionally substituted by cyano, unsubstituted C₃-C₈cycloalkyl₅ phenyl optionally substituted by halogen, and unsubstituted 3-8-members heterocyclyl containing one heteroatom specified in nitrogen and sulphur; R₂ is specified in C₁-C₆alkyl optionally substituted by a 3-member heterocyclyl containing one oxygen heteroatom, and unsubstituted C₃-C₈cycloalkyl, and R₃ represents C₁-C₆alkyl radical for preparing a therapeutic agent for treating an acute or chronic inflammatory disease by inhibiting the production of at least one anti-inflammatory cytokine specified in TNF-alpha and IFN-gamma, or by immunomodulating chemokine IL-8 and/or regulatory cytokine IL-10. The invention also refers to the compounds of formula (I') and the pharmaceutical composition thereof.

EFFECT: preparing the 5-(4-methanesulphonyl phenyl)thiazole derivatives for treating the acute and chronic inflammatory diseases or conditions.

14 cl, 51 tbl, 25 ex