FIELD: biotechnology.
SUBSTANCE: present invention relates to hybrid immunomodulatory proteins, and can be used for induction of dendritic cell maturation (DC) and immunity enhancement. Rv2299c/ESAT-6 hybrid protein consists of ESAT-6 protein fused with Rv2299c, and is capable of inducing aging of the DC. Method for induction of immature DC maturation involves differentiation of mononuclear cells isolated from blood into immature DCs; and treating said immature DCs with Rv2299c/ESAT-6 hybrid protein to provide maturation of said immature DCs to mature DCs. Said fusion protein Rv2299c/ESAT-6 is used in concentration of 1 mcg/ml to 20 mcg/ml.
EFFECT: invention provides preparing a nontoxic immunomodulator for inducing an immune response by stimulating DC differentiation.
9 cl, 12 dwg, 11 ex
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