FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and can be used for treatment of Crohn's disease, ulcerous colitis and type 1 diabetes mellitus. For this purpose applied is APL peptide or its analogues, obtained from a human heat shock protein with a size of 60 kDa (hps60) in order to obtain a pharmaceutical composition. Also claimed are the pharmaceutical composition and the application of a medication for induction of apoptosis of pathogenic clones of T-cells in patients with inflammatory intestinal disease or type 1 diabetes.
EFFECT: group of inventions possesses an immunomodulating action and makes it possible to regulate mechanisms of the peripheral tolerance in gastrointestinal tract.
10 cl, 6 dwg, 6 ex
| Title |
Year |
Author |
Number |
| PHARMACEUTICAL COMPOSITION CONTAINING APL TYPE PEPTIDE |
2018 |
- Dominguez Horta, Maria Del Carmen
- Lopez Abad, Cruz Matilde
- Gonzalez Lopez, Luis Javier
- Besada Perez, Vladimir Armando
|
RU2778402C2 |
| RECOMBINANT CHIMERIC PROTEIN ANTH1, NUCLEIC ACID ENCODING ITS AND THEIR USING |
2003 |
- Bello Rivero Iral'Do
- Torres Ruis Eni
- Blanko Garses Ehlizabet
- Penton Rol' Khisel'E
- Lopes Saura Pedro
|
RU2322455C2 |
| EZRIN DERIVATIVES PEPTIDES AND PHARMACEUTICAL COMPOSITIONS BASED THEREON |
2016 |
- Ataullakhanov Ravshan Inoyatovich
- Ataullakhanov Rustam Ravshanovich
- Sayadyan Khachik Sarkisovich
- Kholms Rupert
|
RU2694906C2 |
| ISOLATED POLYPEPTIDE AND USING IT FOR TREATING MALIGNANT DISEASE AND STIMULATING IMMUNE SYSTEM, PHARMACEUTICAL COMPOSITION CONTAINING SUCH POLYPEPTIDE AND METHOD OF TREATING CANCER |
2008 |
|
RU2518236C2 |
| COP1 FOR TREATMENT OF INFLAMMATORY DISEASES OF INTESTINE |
2004 |
- Akharoni Rina
- Arnon Rut
- Kajkhan Basak
|
RU2339397C2 |
| KOBITOLIMOD FOR USE IN TREATMENT OF INFLAMMATORY BOWEL DISEASE |
2018 |
- Zargari, Arezu
- Edmajr, Sharlotta
- Senduoll, Pernilla
- Knittel, Tomas
- Zerkhuni, Peter
|
RU2766356C2 |
| DPP3-BINDING MOLECULE AIMED AT SPECIFIC DPP3 EPITOPES AND BINDING TO THEM AND ITS USE FOR PREVENTION OR TREATMENT OF DISEASES/ACUTE CONDITIONS, WHICH ARE RELATED TO OXIDATIVE STRESS |
2018 |
|
RU2787033C2 |
| HUMANISED ANTIBODIES SPECIFIC FOR HSP65-DERIVED PEPTIDE-6, METHODS AND USES THEREOF |
2010 |
- Naparstek Yaakov
- Yair Shira
|
RU2596925C2 |
| ANTIBODIES AND POLYPEPTIDES AGAINST CD127 |
2017 |
- Puare, Nikolya
- Mari, Karolina
- Vankhove, Bernard
- Tepene, Virzhini
|
RU2769352C2 |
| ANTISENSE OLIGONUCLEOTIDES (ODN) TO Smad7 AND THEIR APPLICATION IN FIELD OF MEDICINE |
2004 |
|
RU2339697C2 |
