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2 495 033

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(51)

IPC

C07D307/92(2006-01-01)

(21) (22)

Application

2011138643/04, 2011-09-20

(24)

Start date

2011-09-20

(22)

Actual filing date

2011-09-20

(45)

Published

2013-10-10

(72)

Inventor

Osjanin Vitalij AleksandrovichOsipov Dmitrij VladimirovichKlimochkin Jurij Nikolaevich

(73)

Holder

Rossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Obrazovanija I Nauki Rossijskoj FederatsiiFederal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Samarskij Gosudarstvennyj Tekhnicheskij Universitet

METHOD FOR PREPARING 2-(1-ADAMANTYLCARBONYL)-1,2-DIHYDRONAPHTHO [2,1-b] FURANES Russian patent published in 2013 - IPC C07D307/92

Abstract RU 2495033 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for preparing 1,2-dihydronaphtho[2,1-b]furanes containing 1-adamantanoyl group in the second position, by reaction of substituted 1-[(dimethylamino)methyl]-2-naphtholes with 1-[2-(1-adamantyl)-2-oxoethyl]pyridinium bromide in molar ratio 1:1 in the ethanol medium at 78°C in the presence of 1,1,3,3-tetramethylguanidine or 1,8-diazabicyclo[5.4.0]undec-7-ene. These compounds are advanced parent compound for the purpose of the synthesis of pharmacologically active substances.

EFFECT: provided reaction selectivity, simplified process procedure and cost reduction of the production process ensured by using the available naphthalene Mannich bases and storage-stable 1-[2-(1-adamantyl)-2-oxoethyl]pyridinium bromide.

1 cl, 8 ex

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RU 2 495 033 C2

Authors

Osjanin Vitalij Aleksandrovich

Osipov Dmitrij Vladimirovich

Klimochkin Jurij Nikolaevich

Dates

2013-10-10—Published

2011-09-20—Filed